Small Molecules

Biogems

A 83-01

Détails du Produit

Catalog Number: 9094360
Description:
A 83-01 is a potent activing receptor-like kinase inhibitor (ALK4 IC50 45nM, ALK5 IC50 12nM, ALK7 IC50 7.5nM). It is a more potent inhibitor of ALK5 than SB 431542 and is reported to inhibit Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. However, A 83-01 had little or no effect on bone morphogenetic protein type I receptors, p38 mitogen-activated protein kinase, or extracellular regulated kinase. It is used to inhibit differentiation in iPSCs and maintain in vitro cellular self-renewal.

Synonyms: A-83-01, A83-01, ALK5 Inhibitor IV, Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor IV, A083

Application:

Formulation:
Crystalline solid
Chemical Name:
3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
Molecular Formula:

C25H19N5S

Molecular Weight:
421.5
CAS Number:
909910-43-6
Purity:
≥95%

Note:

Product supplied by Biogems

Country Of Origin: USA

Not for human use.