Recombinant Human 4-1BB Ligand 0 ReviewsSubmit a Review Product Details Catalog Number: 310-11 Description: 4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. 4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane protein domain, and a 205 amino acid extracellular domain. The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL. Recombinant Human 4-1BBL is a soluble 19.5 kDa protein consisting of 185 amino acid residues. Source: E.coli Synonyms: TNFSF9, CD137L AA Sequence: MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is 5-10 ng/ml. Please Note: Results may vary with PBMC donors. Calculated Molecular Weight: 19.5 kDa Accession Number: P41273 Gene ID: 8744 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Immune System TNF Superfamily Transplantation Recent Citations First Author Hulley, P A Title Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2. Citation The Journal of Pathology; 242(3) pg322-333 PubMed ID 28418093 First Author Kirouac, D C Title Dynamic interaction networks in a hierarchically organized tissue. Citation Molecular Systems Biology; 6 pg417 PubMed ID 20924352 First Author Houtenbos, I Title Leukemia-specific T-cell reactivity induced by leukemic dendritic cells is augmented by 4-1BB targeting. Citation Clinical cancer research : an official journal of the American Association for Cancer Research; 13(1) pg307-15 PubMed ID 17170077
