Recombinant Human BAFF 0 ReviewsSubmit a Review Product Details Catalog Number: 310-13 Description: BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors, TACI, BCMA and BAFFR. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant Human soluble BAFF is a 152 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF. Source: E.coli Synonyms: B cell Activating Factor belonging to the TNF family, TNFSF13B, TNFSF20, TALL-1, BLyS, THANK, ZNTF4 AA Sequence: AVQGPEETVT QDCLQLIADS ETPTIQKGSY TFVPWLLSFK RGSALEEKEN KILVKETGYF FIYGQVLYTD KTYAMGHLIQ RKKVHVFGDE LSLVTLFRCI QNMPETLPNN SCYSAGIAKL EEGDELQLAI PRENAQISLD GDVTFFGALK LL Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by a mouse splenocyte survival assay. The expected ED50 for this effect is 0.5-2.0 µg/ml. Calculated Molecular Weight: 17 kDa Accession Number: Q9Y275 Gene ID: 10673 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Mouse, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Apoptosis Cancer Immune System Stem Cells & Differentiation TNF Superfamily Recent Citations First Author Sokal, A Title mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants. Citation Immunity; 54(12) pg2893-2907.e5 PubMed ID 34614412 First Author Malinova, D Title Endophilin A2 regulates B-cell endocytosis and is required for germinal center and humoral responses Citation EMBO reports; 22(9) pge51328 PubMed ID 34323351 First Author Monzón-Casanova, E Title Essential requirement for polypyrimidine tract binding proteins 1 and 3 in the maturation and maintenance of mature B cells in mice. Citation European Journal of Immunology; 51(9) pg2266-2273 PubMed ID 34214192
