Recombinant Human BCMA 0 ReviewsSubmit a Review Product Details Catalog Number: 310-16 Description: BCMA, a member of the TNF receptor superfamily, binds to BAFF and APRIL. BCMA is expressed on mature B cells and other B cell lines, and plays an important role in B cell development, function and regulation. BCMA also has the capability to activate NF-κB and JNK. The human BCMA gene codes for a 184 amino acid type I transmembrane protein, which contains a 54 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 107 amino acid cytoplasmic domain. Recombinant soluble Human BCMA is a 50 amino acid polypeptide (5.3 kDa) comprising the TNFR homologous region of the BCMA protein. Source: E.coli Synonyms: B-Cell Maturation Antigen, TNFRSF17, BCM AA Sequence: AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Not available. Calculated Molecular Weight: 5.3 kDa Accession Number: Q02223 Gene ID: 608 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Apoptosis Immune System Inflammation TNF Superfamily Recent Citations First Author Pont, M Title γ-Secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma. Citation Blood; 134(19) pg1585-1597 PubMed ID 31558469
