Recombinant Human Betacellulin 0 ReviewsSubmit a Review Product Details Catalog Number: 100-50 Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant Human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino acid residues, which comprises the mature EGF-homologous portion of the Betacellulin protein. Source: E.coli Synonyms: BTC AA Sequence: DGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg. Calculated Molecular Weight: 9 kDa Accession Number: P35070 Gene ID: 685 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Immune System Neurobiology Stem Cells & Differentiation Recent Citations First Author Jacques, M Title CODEX, a neural network approach to explore signaling dynamics landscapes. Citation Molecular Systems Biology; 17(4) pge10026 PubMed ID 33835701 First Author Shee, K Title Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer. Citation The Journal of Experimental Medicine; 215(3) pg895-910 PubMed ID 29436393 First Author Zhang, D Title Betacellulin Regulates the Proliferation and Differentiation of Retinal Progenitor Cells in Vitro Citation Journal of Cellular and Molecular Medicine; 22 (1), 330-345 PubMed ID 28922560
