Recombinant Human CTGFL/WISP-2 0 ReviewsSubmit a Review Product Details Catalog Number: 120-16 Description: CTGFL/WISP-2 is a 28.6 kDa protein that belongs to the CCN family of cysteine-rich regulatory proteins. Members of this family stimulate mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest, and migration of multiple cell types. The protein is expressed in primary osteoblasts, fibroblasts, the ovaries, testes, and heart. In addition to promoting adhesion of osteoblasts, CTGFL/WISP-2 inhibits osteocalcin production, as well as binding of fibrinogen to integrin receptors. Recombinant Human CTGFL/WISP-2 is a 24.3 kDa protein consisting of 228 amino acid residues. Mature human CTGFL/WISP-2 is a 24.8 kDa polypeptide protein containing 227 amino acids. It is composed of 3 distinct domains; the IGF-Binding Protein domain (IGF-BP), the Thrombospondin type I repeat (TSP type I), and von Willebrand Factor C motif (VWFC). Source: E.coli Synonyms: Connective Tissue Growth Factor-Like protein, CCN5, CT-58 AA Sequence: MQLCPTPCTC PWPPPRCPLG VPLVLDGCGC CRVCARRLGE PCDQLHVCDA SQGLVCQPGA GPGGRGALCL LAEDDSSCEV NGRLYREGET FQPHCSIRCR CEDGGFTCVP LCSEDVRLPS WDCPHPRRVE VLGKCCPEWV CGQGGGLGTQ PLPAQGPQFS GLVSSLPPGV PCPEWSTAWG PCSTTCGLGM ATRVSNQNRF CRLETQRRLC LSRPCPPSRG RSPQNSAF Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is between 10-20 ng/ml in the presence of 15 ng/ml of human IGF-II. Calculated Molecular Weight: 24.3 kDa Accession Number: O76076 Gene ID: 8839 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Immune System Recent Citations First Author Hong, S P Title Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi Citation Nature Communications; 11(1) pg4102 PubMed ID 32796823 First Author Brown, B A Title Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells. Citation Aging Cell; 18(1) pge12844 PubMed ID 30548452
