Recombinant Human FGF-5 0 ReviewsSubmit a Review Product Details Catalog Number: 100-34 Description: FGF-5 is a secreted, heparin-binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-5 binds to FGFR 1c and 2c, and plays a regulatory role in the hair growth cycle. Recombinant Human FGF-5 is a 27.6 kDa protein consisting of 252 amino acid residues. Source: E.coli Synonyms: Fibroblast Growth Factor-5, HBGF-5, Smag-82 AA Sequence: MAWAHGEKRL APKGQPGPAA TDRNPIGSSS RQSSSSAMSS SSASSSPAAS LGSQGSGLEQ SSFQWSPSGR RTGSLYCRVG IGFHLQIYPD GKVNGSHEAN MLSVLEIFAV SQGIVGIRGV FSNKFLAMSK KGKLHASAKF TDDCKFRERF QENSYNTYAS AIHRTEKTGR EWYVALNKRG KAKRGCSPRV KPQHISTHFL PRFKQSEQPE LSFTVTVPEK KNPPSPIKSK IPLSAPRKNT NSVKYRLKFR FG Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by dose-dependent ability to reduce tetrazolium salt, WST-8, by dehydrogenase activities of BaF3 cells expressing FGF receptors using Cell Counting Kit-8 (CCK-8). The expected ED50 is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg. Calculated Molecular Weight: 27.6 kDa Accession Number: P12034 Gene ID: 2250 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Cancer FGF Superfamily Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Recent Citations First Author Hu, H Title Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms. Citation Cancer Cell; 39(11) pg1531-1547.e10 PubMed ID 34624218 First Author Savchenko, E Title FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes. Citation Scientific Reports; 9(1) pg9610 PubMed ID 31270389 First Author Westphal, S Title Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes. Citation Scientific Reports; 9(1) pg8470 PubMed ID 31186471
