Recombinant Human I-309 (CCL1) 0 ReviewsSubmit a Review Product Details Catalog Number: 300-37 Description: I-309 is a CC chemokine that signals through the CCR8 receptor. It is secreted by T-lymphocytes, monocytes and mast cells. I-309 chemoattracts monocytes and Th2 differentiated T-cells, but not neutrophils. Human I-309 is active on murine cells. Recombinant Human I-309 is an 8.5 kDa protein consisting of 74 amino acid residues that include six cysteine residues, of which four are the highly conserved cysteine residues present in CC chemokines. Unlike some CC chemokines, whose biologically active form in solution is a non-disulfide-linked dimer, the biologically active form of I-309 is monomeric. Source: E.coli Synonyms: CCL1, TCA-3 AA Sequence: SKSMQVPFSR CCFSFAEQEI PLRAILCYRN TSSICSNEGL IFKLKRGKEA CALDTVGWVQ RHRKMLRHCP SKRK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human monocytes population using a concentration range of 10.0-30.0 ng/ml. Calculated Molecular Weight: 8.5 kDa Accession Number: P22362 Gene ID: 6346 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Bacteria, Human, Monkey, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Chemotaxis Immune System Neurobiology Wound Healing Recent Citations First Author Galeano Niño, J L Title Cytotoxic T cells swarm by homotypic chemokine signalling. Citation eLIFE; 9 PubMed ID 33046212 First Author Yasuoka, H Title Increased both PD-L1 and PD-L2 expressions on monocytes of patients with hepatocellular carcinoma was associated with a poor prognosis Citation Scientific Reports; 10(1) pg10377 PubMed ID 32587357 First Author Lee, A W Title A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins. Citation The Journal of Biological Chemistry; 294(29) pg11199-11212 PubMed ID 31167786
