Animal-Free Recombinant Human IL-10 0 ReviewsSubmit a Review Product Details Catalog Number: AF-200-10 Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-α. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 is active on murine cells, but murine IL-10 is inactive on human cells. Recombinant Human IL-10 is an 18.6 kDa protein of 161 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: B-TCGF, CSIF, TGIF AA Sequence: MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 18.6 kDa Accession Number: P22301 Gene ID: 3586 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Human, Human + Virus References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Cancer Immune System Inflammation Neurobiology Stem Cells & Differentiation Allergy Transplantation Recent Citations First Author Yamashiro, C Title Benzalkonium chloride-induced myofibroblastic transdifferentiation of Tenon's capsule fibroblasts is inhibited by coculture with corneal epithelial cells or by interleukin-10 Citation Scientific Reports; 11(1) pg16096 PubMed ID 34373467 First Author Braun, D A Title Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation. Citation The Journal of Biological Chemistry; 288(5) pg2986-93 PubMed ID 23166328 First Author Zhao, M Title IL-10 reduces levels of apoptosis in Toxoplasma gondii-infected trophoblasts. Citation PLoS ONE; 8(2) pge56455 PubMed ID 23418570
