Recombinant Human IP-10 (CXCL10) 0 ReviewsSubmit a Review Product Details Catalog Number: 300-12 Description: IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant Human IP-10 is an 8.6 kDa protein consisting of 77 amino acids, including the four conserved cysteine residues present in CXC chemokines. Source: E.coli Synonyms: γ-Interferon Inducible Protein 10, CXCL10, crg-2 AA Sequence: VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human T-Lymphocytes using a concentration of 10-50 ng/ml. Calculated Molecular Weight: 8.6 kDa Accession Number: P02778 Gene ID: 3627 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Bacteria, Human, Human + Hamster, Leech, Monkey, Mouse, Pig References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Chemotaxis Immune System Inflammation Neurobiology Wound Healing Allergy Transplantation Recent Citations First Author Du, Y Title Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation. Citation The Journal of Experimental Medicine; 219(7) PubMed ID 35640018 First Author Gurusamy, M Title G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators. Citation Nature Communications; 12(1) pg6798 PubMed ID 34815397 First Author Ofir-Birin, Y Title Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration Citation Nature Communications; 12(1) pg4851 PubMed ID 34381047
