Recombinant Murine IL-3 2 ReviewsSubmit a Review Product Details Catalog Number: 213-13 Description: IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is a species-specific, variably glycosylated cytokine. Recombinant Murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues. Source: E.coli Synonyms: MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor AA Sequence: MDTHRLTRTL NCSSIVKEII GKLPEPELKT DDEGPSLRNK SFRRVNLSKF VESQGEVDPE DRYVIKSNLQ KLNCCLPTSA NDSALPGVFI RDLDDFRKKL RFYMVHLNDL ETVLTSRPPQ PASGSVSPNR GTVEC Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of murine NFS-60 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 15.1 kDa Accession Number: P01586 Gene ID: 16187 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Bacteria, Gerbil, Human, Monkey, Mouse, Mouse + Human, Mouse + Parasite, Mouse + Virus, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Cancer Cell Culture Diabetes/Weight Regulation Immune System Stem Cells & Differentiation Recent Citations First Author Dai, Y Title Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization. Citation Cell Reports; 40(12) pg111361 PubMed ID 36130501 First Author Weissman, R Title MicroRNA-15a-5p acts as a tumor suppressor in histiocytosis by mediating CXCL10-ERK-LIN28a-let-7 axis. Citation Leukemia; 36(4) pg1139-1149 PubMed ID 34785791 First Author Ahmed, N Title Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation. Citation The Journal of Experimental Medicine; 219(1) PubMed ID 34817548 Product Reviews Existing reviews Better than any other brand Used to treat cells but used different company products and they weren't got delivered it as fast as this one From: Cansu | Date: 7/28/2020 × Better than any other brand Used to treat cells but used different company products and they weren't got delivered it as fast as this one From: Cansu | Date: 7/28/2020 Close Recombinant Murine IL-3 We use this product to make stock dilutions, and store at -20. until we need to prep more murine media. They had always worked well post thaw From: Nichole | Date: 8/26/2020 × Recombinant Murine IL-3 We use this product to make stock dilutions, and store at -20. until we need to prep more murine media. They had always worked well post thaw From: Nichole | Date: 8/26/2020 Close
