Recombinant Human APRIL 0 BewertungenSubmit a Review Produktdetails Katalognummer: 310-10C Beschreibung: APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of the colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, competes for two receptors, TACI and BCMA. APRIL has the ability to stimulate proliferation of various tumor cell lines, including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF-like receptor binding of the APRIL precursor. Recombinant Human APRIL is a soluble 16.3 kDa protein, consisting of 146 amino acid residues. *Human APRIL(Catalog Number 310-10C) has replaced Human APRIL(Catalog Number 310-10) Source: Hi-5 Insect cells Synonyms: A Proliferation-Inducing Ligand, TNFSF13, TRDL-1, TALL-2, CD256 AA Sequence: AVLTQKQKKQ HSVLHLVPIN ATSKDDSDVT EVMWQPALRR GRGLQAQGYG VRIQDAGVYL LYSQVLFQDV TFTMGQVVSR EGQGRQETLF RCIRSMPSHP DRAYNSCYSA GVFHLHQGDI LSVIIPRARA KLNLSPHGTF LGFVKL Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce NF-κB activation in HEK293-NF-κB reporter cells transfected with BCMA receptor. Calculated Molecular Weight: 16.3 kDa Accession Number: O75888 Gene ID: 8741 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 50μg is the largest vial size for this product. Larger sizes supplied as multiple 50μg vials. crossreactivity: Human, Mouse References PubMed SDS Datenblattsuche Product Line Country Of Origin: USA Not for human use. Research Interest Apoptosis Cancer Immune System TNF Superfamily product.subtitle.recentcitations Erstautor Talbot, H Titel BDNF belongs to the nurse-like cell secretome and supports survival of B chronic lymphocytic leukemia cells. Literaturstelle Scientific Reports; 10(1) pg12572 PubMed ID 32724091 Erstautor Lee, C Titel Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis. Literaturstelle Cell death & disease; 9(3) pg401 PubMed ID 29540697 Erstautor Birger, A Titel ALS-related human cortical and motor neurons survival is differentially affected by Sema3A. Literaturstelle Cell death & disease; 9(3) pg256 PubMed ID 29449528