Animal-Free Recombinant Human BAFF 0 BewertungenSubmit a Review Produktdetails Katalognummer: AF-310-13 Beschreibung: BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors, TACI, BCMA and BAFF-R. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant Human soluble BAFF is a 152 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: B cell Activating Factor belonging to the TNF family, TNFSF13B, TNFSF20, TALL-1, BLyS, THANK, ZTNF4 AA Sequence: AVQGPEETVT QDCLQLIADS ETPTIQKGSY TFVPWLLSFK RGSALEEKEN KILVKETGYF FIYGQVLYTD KTYAMGHLIQ RKKVHVFGDE LSLVTLFRCI QNMPETLPNN SCYSAGIAKL EEGDELQLAI PRENAQISLD GDVTFFGALK LL Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by a mouse splenocyte survival assay. The expected ED50 for this effect is 0.5-2.0 µg/ml. Calculated Molecular Weight: 17 kDa Accession Number: Q9Y275 Gene ID: 10673 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS Datenblattsuche Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Apoptosis Cancer Immune System Stem Cells & Differentiation TNF Superfamily product.subtitle.recentcitations Erstautor Mahévas, M Titel B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells. Literaturstelle The Journal of Clinical Investigation; 123(1) pg432-42 PubMed ID 23241960 Erstautor Saada, S Titel Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes. Literaturstelle Journal of immunology (Baltimore, Md. : 1950); 189(11) pg5293-303 PubMed ID 23109725 Erstautor Benson, M J Titel Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells. Literaturstelle Proceedings of the National Academy of Sciences of the United States of America; 109(40) pg16252-7 PubMed ID 22991471
