Recombinant Human FGF-23 0 BewertungenSubmit a Review Produktdetails Katalognummer: 100-52 Beschreibung: The FGF family plays a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-23, FGF-21 and FGF-19 constitute an atypical FGF subfamily whose ligands act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. FGF-23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF-23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1. Recombinant Human FGF-23 is a 25.5 kDa globular protein containing 228 amino acid residues. Source: E.coli Synonyms: Fibroblast Growth Factor-23 AA Sequence: MYPNASPLLG SSWGGLIHLY TATARNSYHL QIHKNGHVDG APHQTIYSAL MIRSEDAGFV VITGVMSRRY LCMDFRGNIF GSHYFDPENC RFQHQTLENG YDVYHSPQYH FLVSLGRAKR AFLPGMNPPP YSQFLSRRNE IPLIHFNTPI PRRHTRSAED DSERDPLNVL KPRARMTPAP ASCSQELPSA EDNSPMASDP LGVVRGGRVN THAGGTGPEG CRPFAKFI Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected ED50 for this effect is 2.0-5.0 μg/ml, in the presence of murine Klotho and heparin. Calculated Molecular Weight: 25.5 kDa Accession Number: Q9GZV9 Gene ID: 8074 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Mouse, Rat References PubMed SDS Datenblattsuche Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Cancer FGF Superfamily Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations Erstautor Cinque, L Titel MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B. Literaturstelle The EMBO Journal; pge105696 PubMed ID 32716134 Erstautor Yamamoto, H Titel Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition. Literaturstelle Bone; 84 pg120-130 PubMed ID 26746780
