Recombinant Human HGF (Insect derived) 2 BewertungenSubmit a Review Produktdetails Katalognummer: 100-39 Beschreibung: HGF is a potent, mesenchymally-derived mitogen for mature parenchymal hepatocytes, and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include the induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear, polypeptide-precursor glycoprotein containing 697 amino acid residues. Proteolytic processing of this precursor generates the biologically active heterodimeric form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held together by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues. Recombinant Human HGF is an 80.0 kDa polypeptide consisting of 697 amino acid residues. Source: (BTI-Tn-5B1-4) Hi-5 Insect cells Synonyms: Hepatocyte Growth Factor, Scatter Factor (SF), Hepatopoietin (HPTA) AA Sequence: alpha chain: QRKRRNTIHE FKKSAKTTLI KIDPALKIKT KKVNTADQCA NRCTRNKGLP FTCKAFVFDK ARKQCLWFPF NSMSSGVKKE FGHEFDLYEN KDYIRNCIIG KGRSYKGTVS ITKSGIKCQP WSSMIPHEHS FLPSSYRGKD LQENYCRNPR GEEGGPWCFT SNPEVRYEVC DIPQCSEVEC MTCNGESYRG LMDHTESGKI CQRWDHQTPH RHKFLPERYP DKGFDDNYCR NPDGQPRPWC YTLDPHTRWE YCAIKTCADN TMNDTDVPLE TTECIQGQGE GYRGTVNTIW NGIPCQRWDS QYPHEHDMTP ENFKCKDLRE NYCRNPDGSE SPWCFTTDPN IRVGYCSQIP NCDMSHGQDC YRGNGKNYMG NLSQTRSGLT CSMWDKNMED LHRHIFWEPD ASKLNENYCR NPDDDAHGPW CYTGNPLIPW DYCPISRCEG DTTPTIVNLD HPVISCAKTK QLR beta chain: VVNGIPTRTN IGWMVSLRYR NKHICGGSLI KESWVLTARQ CFPSRDLKDY EAWLGIHDVH GRGDEKCKQV LNVSQLVYGP EGSDLVLMKL ARPAVLDDFV STIDLPNYGC TIPEKTSCSV YGWGYTGLIN YDGLLRVAHL YIMGNEKCSQ HHRGKVTLNE SEICAGAEKI GSGPCEGDYG GPLVCEQHKM RMVLGVIVPG RGCAIPNRPG IFVRVAYYAK WIHKIILTYK VPQS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of monkey 4MBr-5 cells. The expected ED50 for this effect is 1.0-20.0 ng/ml. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 80 kDa Accession Number: P14210 Gene ID: 3082 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 250μg is the largest vial size for this product. Larger sizes supplied as multiple 250μg vials. crossreactivity: Dog, Human, Human + Mouse, Leech, Monkey, Mouse, Mouse + Human, Rabbit, Rat References PubMed SDS Datenblattsuche Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Angiogenesis/Cardiovascular Cancer Immune System Neurobiology Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations Erstautor Nguyen, V V Titel A human kidney and liver organoid-based multi-organ-on-a-chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell-derived extracellular vesicles. Literaturstelle Journal Of Extracellular Vesicles; 11(11) pge12280 PubMed ID 36382606 Erstautor Lui, V C Titel Human liver organoid derived intra-hepatic bile duct cells support SARS-CoV-2 infection and replication. Literaturstelle Scientific Reports; 12(1) pg5375 PubMed ID 35354880 Erstautor Kawase, N Titel SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells. Literaturstelle The Journal of Biological Chemistry; 298(3) pg101630 PubMed ID 35085554 product.subtitle.productreviews Vorliegende Bewertungen Good quality product and excellent service I have had great results and excellent service from Peprotech. hHGF (insect derived) always worked as expected and consistently for developing liver oragnoids. Von: Afshan | Datum: 28.07.2020 × Good quality product and excellent service I have had great results and excellent service from Peprotech. hHGF (insect derived) always worked as expected and consistently for developing liver oragnoids. Von: Afshan | Datum: 28.07.2020 Close Hepatocyte Growth Factor for Liver Cancer Organoid Culture Using HGF, Able to culture the Hepatobilliary Cancer Organoids.Quick Next day delivery is great. Von: Hardik | Datum: 31.08.2020 × Hepatocyte Growth Factor for Liver Cancer Organoid Culture Using HGF, Able to culture the Hepatobilliary Cancer Organoids.Quick Next day delivery is great. Von: Hardik | Datum: 31.08.2020 Close
