Animal-Free Recombinant Human IFN-λ1 0 BewertungenSubmit a Review Produktdetails Katalognummer: AF-300-02L Beschreibung: IFN λ1, 2, and 3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and the interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defenses similar to, but distinct from, that of type I interferons. Recombinant Human IFN-λ1 is a 19.8 kDa protein containing 178 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: IL-29 AA Sequence: PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml. Calculated Molecular Weight: 19.8 kDa Accession Number: Q8IU54 Gene ID: 282618 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Human, Monkey References PubMed SDS Datenblattsuche Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Diabetes/Weight Regulation Immune System product.subtitle.recentcitations Erstautor Nitta, S Titel Effects of Resistance-Associated NS5A Mutations in Hepatitis C Virus on Viral Production and Susceptibility to Antiviral Reagents. Literaturstelle Scientific Reports; 6 pg34652 PubMed ID 27703205 Erstautor Yin, Z Titel Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells. Literaturstelle Journal of immunology (Baltimore, Md. : 1950); 189(6) pg2735-45 PubMed ID 22891284 Erstautor Hastie, M L Titel The human respiratory syncytial virus nonstructural protein 1 regulates type I and type II interferon pathways. Literaturstelle Molecular & cellular proteomics : MCP; 11(5) pg108-27 PubMed ID 22322095
