Recombinant Human BAFF Receptor 0 AvisSubmit a Review Détails du Produit Catalog Number: 310-13R Description: BAFF Receptor (BAFFR), a member of the TNFR superfamily, is highly expressed in the spleen, lymph nodes, and resting B cells, and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFFR is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B). BAFFR/BAFF signaling plays a critical role in B cell survival and maturation. Recombinant Human BAFFR is a 76 amino acid polypeptide (7.7 kDa) corresponding to the extracellular portion of the full BAFFR protein. Source: E.coli Synonyms: BAFFR, TNFRSF13C, BLyS receptor 3 AA Sequence: MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 2.0-4.0 μg/ml in the presence of 1.0μg/ml of human soluble BAFF. Calculated Molecular Weight: 7.7 kDa Accession Number: Q96RJ3 Gene ID: 115650 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Mouse, References PubMed SDS Recherche de CoA Product Line Country Of Origin: USA Not for human use. Research Interest Immune System Receptors Stem Cells & Differentiation TNF Superfamily product.subtitle.recentcitations Premier Auteur Dong, Z Titre Generation of a humanized afucosylated BAFF-R antibody with broad activity against human B-cell malignancies. Citation Blood Advances; 7(6) pg918-932 Id PubMed 36469551 Premier Auteur Zhang, S Titre RhoA of the Rho family small GTPases is essential for B lymphocyte development. Citation PLoS ONE; 7(3) pge33773 Id PubMed 22438996
