Recombinant Human ENA-78 (CXCL5) (5-78 a.a.) 0 AvisSubmit a Review Détails du Produit Catalog Number: 300-22 Description: ENA-78 is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78 is a chemoattractant for neutrophils. The three naturally occurring variants of human ENA-78; ENA 5-78, ENA 9-78 and ENA 10-78, contain 74, 70, and 69 amino acid residues, respectively, and possess the same biological activity. ENA-78 contains the four conserved cysteine residues present in CXC chemokines, and also contains the 'ELR' motif common to CXC chemokines that bind to the CXCR1 and CXCR2 receptors. Recombinant Human ENA-78 is an 8.0 kDa protein consisting of 74 amino acid residues. Source: E.coli Synonyms: Epithelial Neutrophil Activating Peptide-78, CXCL5 AA Sequence: AAVLRELRCV CLQTTQGVHP KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK KVIQKILDGG NKEN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration of 5.0-10.0 ng/ml. Calculated Molecular Weight: 8 kDa Accession Number: P42830 Gene ID: 6374 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Hamster, Human, Mouse References PubMed SDS Recherche de CoA Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Chemotaxis Immune System Inflammation Wound Healing product.subtitle.recentcitations Premier Auteur Du, Y Titre Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation. Citation The Journal of Experimental Medicine; 219(7) Id PubMed 35640018 Premier Auteur Li, Q Titre mRNA-engineered mesenchymal stromal cells expressing CXCR2 enhances cell migration and improves recovery in IBD. Citation Molecular therapy. Nucleic acids; 26 pg222-236 Id PubMed 34513306 Premier Auteur Fonseca, K L Titre Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils Citation Mucosal Immunology; 13(5) pg836-848 Id PubMed 32203062