Recombinant Human gAcrp30/Adipolean 0 AvisSubmit a Review Détails du Produit Catalog Number: 450-21 Description: gAcrp30 is a naturally occurring globular protein obtained by proteolytic processing of adiponectin. Adiponectin is produced and secreted exclusively by adipocytes, and is a relatively abundant plasma protein, accounting for up to 0.05% of total serum protein. Like Adiponectin, gAcrp30 is capable of decreasing hyperglycemia and reversing insulin resistance. Additionally, gAcrp30 has been shown to be an important factor in promoting fat loss by signaling muscle to absorb and burn Free-Fatty Acids (FFAs). The signaling receptors for adiponectin and gAcrp30 have recently been identified and named AdipoR1 and AdipoR2. AdipoR2 is predominantly expressed in the liver. Recombinant Human gAcrp30/Adipolean is a 16.6 kDa protein consisting of 145 amino acid residues. Source: E.coli Synonyms: APM-1, Adipolean (human), gad, globular domain of Acrp30 AA Sequence: MKGEPGEGAY VYRSAFSVGL ETYVTIPNMP IRFTKIFYNQ QNHYDGSTGK FHCNIPGLYY FAYHITVYMK DVKVSLFKKD KAMLFTYDQY QENNVDQASG SVLLHLEVGD QVWLQVYGEG ERNGLYADND NDSTFTGFLL YHDTN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit the proliferation of murine M1 cells. The expected ED50 for this effect is 1.0-3.0 μg/ml. Calculated Molecular Weight: 16.6 kDa Accession Number: Q15848 Gene ID: 9370 Endotoxin: Endotoxin level is < 0.2 ng/ug of protein (< 2 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse, Rat References PubMed SDS Recherche de CoA Product Line Country Of Origin: USA Not for human use. Research Interest Diabetes/Weight Regulation product.subtitle.recentcitations Premier Auteur Dubessy, A Titre Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS. Citation Glia; 67(12) pg2248-2263 Id PubMed 31328333 Premier Auteur Tilija Pun, N Titre Critical role of tristetraprolin and AU-rich element RNA-binding protein 1 in the suppression of cancer cell growth by globular adiponectin. Citation FEBS Open Bio; 8(12) pg1964-1976 Id PubMed 30524947 Premier Auteur Tishinsky, J M Titre Fish oil prevents high-saturated fat diet-induced impairments in adiponectin and insulin response in rodent soleus muscle. Citation American journal of physiology. Regulatory, integrative and comparative physiology; 302(5) pgR598-605 Id PubMed 22204953