Animal-Free Recombinant Human IL-1RA 0 AvisSubmit a Review Détails du Produit Catalog Number: AF-200-01RA Description: Interleukin-1 receptor antagonist (IL-1RA) is a naturally-occurring, inflammatory-inhibitor protein. It inhibits the activity of IL-1α and IL-1β by competitively blocking their binding to type I and type II receptors. IL-1RA is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant Human IL-1RA is a 17.2 kDa protein consisting of 153 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: IL-1Ra, ICIL-1RA, IRAP, IL-1RN AA Sequence: MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit the IL-1α stimulation of murine D10S cell. The expected ED50 is 20-40 ng/ml in the presence of 50 pg/ml of IL-1alpha. Calculated Molecular Weight: 17.2 kDa Accession Number: P18510 Gene ID: 3554 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Frog, Human, Mouse, Rat References PubMed SDS Recherche de CoA Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Diabetes/Weight Regulation Immune System Inflammation Neurobiology product.subtitle.recentcitations Premier Auteur Laucirica, D R Titre Pseudomonas aeruginosa modulates neutrophil granule exocytosis in an in vitro model of airway infection. Citation Immunology and Cell Biology; 100(5) pg352-370 Id PubMed 35318736 Premier Auteur Iyer, A Titre MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response. Citation PLoS ONE; 7(9) pge44789 Id PubMed 23028621
