Recombinant Human MIP-1β (CCL4) 0 AvisSubmit a Review Détails du Produit Catalog Number: 300-09 Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1α and MIP-1β exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes, and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant Human MIP-1β is a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. Source: E.coli Synonyms: Macrophage Inflammatory Protein-1β, CCL4, ACT-2 AA Sequence: APMGSDPPTA CCFSYTARKL PHNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml. Calculated Molecular Weight: 7.6 kDa Accession Number: P13236 Gene ID: 6351 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Hamster, Human, Monkey, Mouse, Pig, Rat References PubMed SDS Recherche de CoA Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Chemotaxis Immune System Inflammation Neurobiology Wound Healing Transplantation product.subtitle.recentcitations Premier Auteur Du, Y Titre Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation. Citation The Journal of Experimental Medicine; 219(7) Id PubMed 35640018 Premier Auteur Gurusamy, M Titre G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators. Citation Nature Communications; 12(1) pg6798 Id PubMed 34815397 Premier Auteur Murcia, J D Titre Atypical chemokine receptor ACKR2-V41A has decreased CCL2 binding, scavenging, and activation, supporting sustained inflammation and increased Alzheimer's disease risk Citation Scientific Reports; 10(1) pg8019 Id PubMed 32415244