Recombinant Human Resistin 0 AvisSubmit a Review Détails du Produit Catalog Number: 450-19 Description: Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The four known members of this family, resistin, RELMα, RELMβ, and RELMγ, share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that resistin expression is severely suppressed in obesity, and that it may act as a feedback regulator of Adipogenesis. Recombinant Human Resistin is a 19.5 kDa, disulfide-linked, homodimeric protein composed of two identical 92 amino acid chains linked by a single disulfide bond. Source: E.coli Synonyms: FIZZ3, Adipose tissue-specific secretory factor, ADSF AA Sequence (monomer): SSKTLCSMEE AINERIQEVA GSLIFRAISS IGLECQSVTS RGDLATCPRG FAVTGCTCGS ACGSWDVRAE TTCHCQCAGM DWTGARCCRV QP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate lipolysis in cultured human adipocytes. (Ort, T. et al. Endocrinology; 46(5):2200-9) Calculated Molecular Weight: 19.5 kDa Accession Number: Q9HD89 Gene ID: 56729 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Human, Mouse References PubMed SDS Recherche de CoA Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Diabetes/Weight Regulation Immune System Inflammation product.subtitle.recentcitations Premier Auteur Zhang, L Titre Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer. Citation Cell; 181(2) pg442-459.e29 Id PubMed 32302573 Premier Auteur Joshi, P Titre The membrane-associated fraction of cyclase associate protein 1 translocates to the cytosol upon platelet stimulation. Citation Scientific Reports; 8(1) pg10804 Id PubMed 30018317 Premier Auteur Jang, J C Titre Human resistin protects against endotoxic shock by blocking LPS-TLR4 interaction. Citation Proceedings of the National Academy of Sciences of the United States of America; 114(48) pgE10399-E10408 Id PubMed 29133417