Recombinant Murine MIP-1β (CCL4) 0 AvisSubmit a Review Détails du Produit Catalog Number: 250-32 Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (.g. macrophages, lymphocytes and NK cells). While both MIP-1α and MIP-1β exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes, and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant Murine MIP-1β is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. Source: E.coli Synonyms: Macrophage Inflammatory Protein-1β, CCL4, ACT-2 AA Sequence: APMGSDPPTS CCFSYTSRQL HRSFVMDYYE TSSLCSKPAV VFLTKRGRQI CANPSEPWVT EYMSDLELN Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 20.0-100.0 ng/ml. Calculated Molecular Weight: 7.8 kDa Accession Number: P14097 Gene ID: 20303 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Hamster, Human, Mouse, References PubMed SDS Recherche de CoA Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Chemotaxis Immune System Inflammation Neurobiology Wound Healing Transplantation product.subtitle.recentcitations Premier Auteur Galeano Niño, J L Titre Cytotoxic T cells swarm by homotypic chemokine signalling. Citation eLIFE; 9 Id PubMed 33046212 Premier Auteur Martín-Leal, A Titre CCR5 deficiency impairs CD4+ T-cell memory responses and antigenic sensitivity through increased ceramide synthesis. Citation The EMBO Journal; 39(15) pge104749 Id PubMed 32525588 Premier Auteur He, H Titre Aging-induced IL27Ra signaling impairs hematopoietic stem cells. Citation Blood; 136(2) pg183-198 Id PubMed 32305041