Recombinant Murine β-NGF

Détails du Produit

Catalog Number: 450-34

Description:

β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. The functional form of Recombinant Murine β-NGF is a non-covalently-linked homodimer of two 13.4 kDa, polypeptide monomers that each contain 120 amino acids and three disulfide bonds, which are required for biological activity.

Source: E.coli

Synonyms: NGF-β, beta-Nerve Growth Factor

AA Sequence (monomer): SSTHPVFHMG EFSVCDSVSV WVGDKTTATD IKGKEVTVLA EVNINNSVFR QYFFETKCRA SNPVESGCRG IDSKHWNSYC TTTHTFVKAL TTDEKQAAWR FIRIDTACVC VLSRKATRRG

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁶ units/mg.

Calculated Molecular Weight: 26.8 kDa

Accession Number: P01139

Gene ID: 18049

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:

Human, Mouse, Rat

Country Of Origin: USA

Not for human use.

Research Interest

Angiogenesis/Cardiovascular

Chemotaxis

Diabetes/Weight Regulation

Immune System

Inflammation

Neurobiology

Stem Cells & Differentiation

Wound Healing

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Neurotrophines