Recombinant Human BMP-10 0 评论Submit a Review 产品详情 产品编号: 120-40 产品描述: Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes. BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration. Recombinant Human BMP-10 is a 24.4 kDa homodimeric disulfide-linked protein consisting of two 108 amino acid subunits, which correspond to amino acid residues 317 to 424 of the full-length BMP-10 precursor. Source: HEK293 cells Synonyms: Bone Morphogenetic Protein-10 AA Sequence (monomer): NAKGNYCKRT PLYIDFKEIG WDSWIIAPPG YEAYECRGVC NYPLAEHLTP TKHAIIQALV HLKNSQKASK ACCVPTKLEP ISILYLDKGV VTYKFKYEGM AVSECGCR Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 4.0-6.0 ng/ml. Calculated Molecular Weight: 24.4 kDa Accession Number: O95393 Gene ID: 27302 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 细胞凋亡 骨/骨骼系统/软骨 细胞培养 干细胞&分化 TGF-β超家族 product.subtitle.recentcitations 第一作者 Shee, K 标题 Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer. 文献引用 The Journal of Experimental Medicine; 215(3) pg895-910 PubMed Id 29436393 第一作者 Junk, D J 标题 Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling. 文献引用 Oncogene; 36(28) pg4001-4013 PubMed Id 28288136