Recombinant Human BMP-4 (E.coli derived) 0 评论Submit a Review 产品详情 产品编号: 120-05ET 产品描述: Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body, and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. PeproTech’s E.coli-derived BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor. The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 23.9 kDa. Source: E.coli Synonyms: Bone Morphogenetic Protein-4, BMP-2B, DVR4 AA Sequence (monomer): KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml. Calculated Molecular Weight: 23.9 kDa Accession Number: P12644 Gene ID: 652 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse, Pig, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest Organoids 血管生成/心血管 细胞凋亡 骨/骨骼系统/软骨 细胞培养 免疫系统 神经生物学 干细胞&分化 TGF-β超家族 product.subtitle.recentcitations 第一作者 Jacobo Lopez, A 标题 Retinal organoids derived from rhesus macaque iPSCs undergo accelerated differentiation compared to human stem cells. 文献引用 Cell Proliferation; 55(4) pge13198 PubMed Id 35165951 第一作者 Aykul, S 标题 BMP-4 Extraction from Extracellular Matrix and Analysis of Heparin-Binding Properties. 文献引用 Molecular Biotechnology; 64(2) pg156-170 PubMed Id 34550550 第一作者 Frey, P 标题 SMAD4 mutations do not preclude epithelial-mesenchymal transition in colorectal cancer. 文献引用 Oncogene; 41(6) pg824-837 PubMed Id 34857888