Recombinant Human FGF-21 0 评论Submit a Review 产品详情 产品编号: 100-42 产品描述: FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of β-Klotho as a protein cofactor, signals through the FGFR 1c and 4 receptors, and stimulates insulin-independent glucose uptake by adipocytes. Recombinant Human FGF-21 is a 19.5 kDa protein containing 182 amino acid residues. Source: E.coli Synonyms: Fibroblast Growth Factor-21, FGFL AA Sequence: MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS Purity: ≥ 90% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. Calculated Molecular Weight: 19.5 kDa Accession Number: Q9NSA1 Gene ID: 26291 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 骨/骨骼系统/软骨 癌症 FGF超家族 免疫系统 炎症 神经生物学 干细胞&分化 创伤修复 product.subtitle.recentcitations 第一作者 Wu, T 标题 Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway. 文献引用 The Journal of Experimental Medicine; 218(6) PubMed Id 33856409 第一作者 Kim, H Y 标题 Hepatic STAMP2 mediates recombinant FGF21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease. 文献引用 FASEB journal : official publication of the Federation of American Societies for Experimental Biology; 34(9) pg12354-12366 PubMed Id 32721044 第一作者 Cinque, L 标题 MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B. 文献引用 The EMBO Journal; pge105696 PubMed Id 32716134