Recombinant Human HB-EGF 0 评论Submit a Review 产品详情 产品编号: 100-47 产品描述: HB-EGF is an EGF-related growth factor that signals through the EGF receptor, and stimulates the proliferation of smooth muscle cells (SMC), fibroblasts, epithelial cells, and keratinocytes. HB-EGF is expressed in numerous cell types and tissues, including vascular endothelial cells, and vascular SMC, macrophages, skeletal muscle, keratinocytes, and certain tumor cells. The ability of HB-EGF to specifically bind heparin and heparin sulfate proteoglycans is distinct from other EGF-like molecules, and may be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells. The human HB-EGF gene encodes a 208 amino acid transmembrane protein, which can be proteolytically cleaved to produce soluble HB-EGF. Recombinant Human HB-EGF is a 9.7 kDa protein containing 86 amino acid residues, corresponding to the extracellular EGF-like and heparin-binding domains of the full length HB-EGF protein. Source: E.coli Synonyms: Heparin Binding EGF-like growth factor, HBEGF, Diphtheria toxin receptor (DTR) AA Sequence: DLQEADLDLL RVTLSSKPQA LATPNKEEHG KRKKKGKGLG KKRDPCLRKY KDFCIHGECK YVKELRAPSC ICHPGYHGER CHGLSL Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. Calculated Molecular Weight: 9.7 kDa Accession Number: Q99075 Gene ID: 1839 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 细胞凋亡 免疫系统 神经生物学 干细胞&分化 创伤修复 product.subtitle.recentcitations 第一作者 Yu, S 标题 A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1. 文献引用 Advanced science (Weinheim, Baden-Wurttemberg, Germany); 8(19) pge2101848 PubMed Id 34363355 第一作者 Hara, T 标题 Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. 文献引用 Cancer Cell; 39(6) pg779-792.e11 PubMed Id 34087162 第一作者 Ebisudani, T 标题 Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening. 文献引用 Cell Reports; 35(10) pg109218 PubMed Id 34038715