Recombinant Human Heregulinβ-1 1 评论Submit a Review 产品详情 产品编号: 100-03 产品描述: Neuregulin/Heregulin is a family of structurally-related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms releases soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain; the latter is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity that leads to tyrosine phosphorylation. Although HRG1-β1's biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells, which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant Human Heregulinβ-1 (HRG1-B1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulinβ-1 (65 amino acid residues). Source: E.coli Synonyms: Neuregulin1 (NRG1-β1), Neu differentiation factor (rat), HRG, HRG1-β1, Breast cancer cell differentiation factor p45, ARIA (Acetylcholine, Receptor Inducing Activity), glial growth factor AA Sequence: SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg. Calculated Molecular Weight: 7.5 kDa Accession Number: Q02297 Gene ID: 3084 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Dog, Human, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest Organoids 血管生成/心血管 细胞凋亡 癌症 免疫系统 神经生物学 干细胞&分化 product.subtitle.recentcitations 第一作者 Yoon, Y 标题 Salivary gland organoid culture maintains distinct glandular properties of murine and human major salivary glands. 文献引用 Nature Communications; 13(1) pg3291 PubMed Id 35672412 第一作者 Peschke, K 标题 Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems. 文献引用 EMBO Molecular Medicine; 14(4) pge14876 PubMed Id 35119792 第一作者 Li, Z 标题 Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide. 文献引用 The Journal of Clinical Investigation; 132(1) PubMed Id 34981789 product.subtitle.productreviews 现有评论 Great for organoids! We use this in specific patient tumor organoid media and have wonderful results. 来自: Julie-Ann | 日期: 2021/8/3 × Great for organoids! We use this in specific patient tumor organoid media and have wonderful results. 来自: Julie-Ann | 日期: 2021/8/3 Close