Recombinant Human IL-13 1 评论Submit a Review 产品详情 产品编号: 200-13 产品描述: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 are cross-species reactive. Recombinant Human IL-13 is a 12.6 kDa protein consisting of 115 amino acid residues. Source: E.coli Synonyms: NC30 (Human), P600 (Murine) AA Sequence: MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGRFN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 12.6 kDa Accession Number: P35225 Gene ID: 3596 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Human, Human + Mouse, Monkey, Mouse, Pig References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 艾滋病/HIV 癌症 免疫系统 炎症 干细胞&分化 过敏 product.subtitle.recentcitations 第一作者 Jiménez-Andrade, Y 标题 The Developmental Transcription Factor p63 Is Redeployed to Drive Allergic Skin Inflammation through Phosphorylation by p38α. 文献引用 Journal of immunology (Baltimore, Md. : 1950); 208(12) pg2613-2621 PubMed Id 35623662 第一作者 Jiang, M 标题 Pyridoxamine ameliorates methylglyoxal-induced macrophage dysfunction to facilitate tissue repair in diabetic wounds. 文献引用 International Wound Journal; 19(1) pg52-63 PubMed Id 33792156 第一作者 Liu, Y 标题 Histone deacetylase 9 deficiency exaggerates uterine M2 macrophage polarization. 文献引用 Journal of Cellular and Molecular Medicine; 25(16) pg7690-7708 PubMed Id 34145738 product.subtitle.productreviews 现有评论 Good I have used the vial before in the lab, and have got the desired results. that is why I have ordwred the same vial again. because I trust the product 来自: E | 日期: 2020/8/27 × Good I have used the vial before in the lab, and have got the desired results. that is why I have ordwred the same vial again. because I trust the product 来自: E | 日期: 2020/8/27 Close