Recombinant Human IL-1RA 0 评论Submit a Review 产品详情 产品编号： 200-01RA 产品描述： Interleukin-1 receptor antagonist (IL-1RA) is a naturally-occurring, inflammatory-inhibitor protein. It inhibits the activity of IL-1α and IL-1β by competitively blocking their binding to type I and type II receptors. IL-1RA is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant Human IL-1RA is a 17.2 kDa protein consisting of 153 amino acid residues. Source: E.coli AA Sequence: MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE Synonyms: IL-1Ra, ICIL-1RA, IRAP, IL-1RN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit the IL-1α stimulation of murine D10S cell. The expected ED50 is 20-40 ng/ml in the presence of 50 pg/ml of IL-1α. Calculated Molecular Weight: 17.2 kDa Accession Number: P18510 Gene ID: 3554 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Frog, Human, Human + Virus, Mouse, Mouse + Virus, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 糖尿病/体重调节 免疫系统 炎症 神经生物学 product.subtitle.recentcitations 第一作者 Bouhaddou, M 标题 The Global Phosphorylation Landscape of SARS-CoV-2 Infection. 文献引用 Cell; 182(3) pg685-712.e19 PubMed Id 32645325 第一作者 Xie, C B 标题 Complement-activated interferon-γ-primed human endothelium transpresents interleukin-15 to CD8+ T cells. 文献引用 The Journal of Clinical Investigation; 130(7) pg3437-3452 PubMed Id 32191642 第一作者 Wang, Q 标题 Hypertonic saline mediates the NLRP3/IL-1β signaling axis in microglia to alleviate ischemic blood-brain barrier permeability by downregulating astrocyte-derived VEGF in rats. 文献引用 CNS Neuroscience &Amp; Therapeutics; PubMed Id 32529750
