Recombinant Human MIP-1β (CCL4) 0 评论Submit a Review 产品详情 产品编号: 300-09 产品描述: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1α and MIP-1β exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes, and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant Human MIP-1β is a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. Source: E.coli Synonyms: Macrophage Inflammatory Protein-1β, CCL4, ACT-2 AA Sequence: APMGSDPPTA CCFSYTARKL PHNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml. Calculated Molecular Weight: 7.6 kDa Accession Number: P13236 Gene ID: 6351 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Hamster, Human, Monkey, Mouse, Pig, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 艾滋病/HIV 化学趋化 免疫系统 炎症 神经生物学 创伤修复 移植 product.subtitle.recentcitations 第一作者 Du, Y 标题 Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation. 文献引用 The Journal of Experimental Medicine; 219(7) PubMed Id 35640018 第一作者 Gurusamy, M 标题 G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators. 文献引用 Nature Communications; 12(1) pg6798 PubMed Id 34815397 第一作者 Murcia, J D 标题 Atypical chemokine receptor ACKR2-V41A has decreased CCL2 binding, scavenging, and activation, supporting sustained inflammation and increased Alzheimer's disease risk 文献引用 Scientific Reports; 10(1) pg8019 PubMed Id 32415244