Animal-Free Recombinant Human β-NGF 0 评论Submit a Review 产品详情 产品编号: AF-450-01 产品描述: β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. The functional form of Recombinant Human β-NGF is a non-covalently-linked homodimer of two 13.5 kDa, polypeptide monomers that each contain 120 amino acids and three disulfide bonds, which are required for biological activity. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: NGF-β, beta-Nerve Growth Factor AA Sequence (monomer): SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. Calculated Molecular Weight: 27 kDa Accession Number: P01138 Gene ID: 4803 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Chicken, Hamster, Human, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 化学趋化 糖尿病/体重调节 免疫系统 炎症 神经生物学 干细胞&分化 创伤修复 product.subtitle.recentcitations 第一作者 Moses, C 标题 Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing 文献引用 Scientific Reports; 10(1) pg11393 PubMed Id 32647121 第一作者 Schira-Heinen, J 标题 Functional omics analyses reveal only minor effects of microRNAs on human somatic stem cell differentiation 文献引用 Scientific Reports; 10(1) pg3284 PubMed Id 32094412 第一作者 Cui, Y 标题 Stepwise optimization of the procedure for assessment of circulating progenitor cells in patients with myocardial infarction. 文献引用 PLoS ONE; 7(1) pge30389 PubMed Id 22272341