Recombinant Human OPG 0 评论Submit a Review 产品详情 产品编号： 450-14 产品描述： Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. OPG is expressed in a wide variety of tissues, including the adult heart, lung, kidney, liver, spleen, prostate, lymph node, and bone marrow. OPG is secreted both as a monomeric and a dimeric protein. Its primary structure consists of seven distinct domains, four of which correspond to the extracellular cysteine-rich domains of TNFR proteins and constitute the soluble OPG. Recombinant Human OPG is a soluble 20.0 kDa protein containing 174 amino acid residues. Source: E.coli Synonyms: TNFRSF11B, Osteoprotegerin, OCIF (osteoclastogenesis inhibitory factor), TR1 AA Sequence: METFPPKYLH YDEETSHQLL CDKCPPGTYL KQHCTAKWKT VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT HNRVCECKEG RYLEIEFCLK HRSCPPGFGV VQAGTPERNT VCKRCPDGFF SNETSSKAPC RKHTNCSVFG LLLTQKGNAT HDNICSGNSE STQK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit TRAIL-induced apoptosis of LN-18 glioblastoma cells. Calculated Molecular Weight: 20 kDa Accession Number: O00300 Gene ID: 4982 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 细胞凋亡 骨/骨骼系统/软骨 癌症 免疫系统 受体 TNF超家族 product.subtitle.recentcitations 第一作者 Brito, H O 标题 Immune-mediated febrile response in female rats: Role of central hypothalamic mediators. 文献引用 Scientific Reports; 10(1) pg4073 PubMed Id 32139801 第一作者 Gooding, S 标题 Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease. 文献引用 Nature Communications; 10(1) pg4533 PubMed Id 31586071 第一作者 Ochiai, N 标题 Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment. 文献引用 Communications Biology; 2 pg86 PubMed Id 30854478
