Recombinant Human PDGF-AB 1 评论Submit a Review 产品详情 产品编号: 100-00AB 产品描述: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-AB is a 26.4 kDa disulfide-linked dimer, consisting of one α chain and one β chain (234 total amino acids). Source: E.coli Synonyms: Platelet-Derived Growth Factor-AB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF), PCGF AA Sequence: Alpha chain: SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPTBeta chain: SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by Balb/c 3T3 cells is ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. Calculated Molecular Weight: 26.4 kDa Accession Number: Alpha: P04085 Beta: P01127 Gene ID: Alpha: 5154 Beta: 5155 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Guinea Pig, Human, Monkey, Mouse References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 骨/骨骼系统/软骨 癌症 免疫系统 神经生物学 干细胞&分化 创伤修复 product.subtitle.recentcitations 第一作者 Pandey, H S 标题 Coronin 1A facilitates calcium mobilization and promotes astrocyte reactivity in HIV-1 neuropathogenesis. 文献引用 FASEB BioAdvances; 4(4) pg254-272 PubMed Id 35415462 第一作者 Meier, S 标题 Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation 文献引用 Cell Death & Disease; 12(8) pg785 PubMed Id 34381018 第一作者 Geuder, J 标题 A non-invasive method to generate induced pluripotent stem cells from primate urine 文献引用 Scientific Reports; 11(1) pg3516 PubMed Id 33568724 product.subtitle.productreviews 现有评论 Easy to reconstitute and store for long-term usage The item came fast, it's easy to reconstitute and there's enough options to indicate storage and usage at given temperatures. It's worked well in a variety of assays and I will continue to use this product. 来自: Vikram | 日期: 2020/7/22 × Easy to reconstitute and store for long-term usage The item came fast, it's easy to reconstitute and there's enough options to indicate storage and usage at given temperatures. It's worked well in a variety of assays and I will continue to use this product. 来自: Vikram | 日期: 2020/7/22 Close