Recombinant Human R-Spondin-1 4 评论Submit a Review 产品详情 产品编号： 120-38 产品描述： R-Spondin-1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing the furin-like and thrombospondin structural domains. Rspo-1 is expressed in certain areas of the developing central nervous system, as well as in the adrenal glands, ovary, testis, thyroid, and trachea. Rspo can interact with the Frizzled/LRP6 receptor complex in a manner that stimulates the Wnt/β-catenin signaling pathway. Recombinant Human R-Spondin-1 is a 26.7 kDa protein consisting of 243 amino acid residues. Due to glycosylation, R-Spondin-1 migrates at an apparent molecular weight of approximately 40.0 kDa by SDS-PAGE analysis under reducing conditions. Source: CHO cells Synonyms: Roof plate-specific spondin-1, RSPO1 AA Sequence: SRGIKGKRQR RISAEGSQAC AKGCELCSEV NGCLKCSPKL FILLERNDIR QVGVCLPSCP PGYFDARNPD MNKCIKCKIE HCEACFSHNF CTKCKEGLYL HKGRCYPACP EGSSAANGTM ECSSPAQCEM SEWSPWGPCS KKQQLCGFRR GSEERTRRVL HAPVGDHAAC SDTKETRRCT VRRVPCPEGQ KRRKGGQGRR ENANRNLARK ESKEAGAGSR RRKGQQQQQQ QGTVGPLTSA GPA Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: R-Spondin-1 enhances BMP-2-mediated differentiation of MC3T3-E1 cells. The expected ED50 is 1.0-3.0 μg/ml. Calculated Molecular Weight: 26.7 kDa Accession Number: Q2MKA7 Gene ID: 284654 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest Organoids 癌症 神经生物学 干细胞&分化 product.subtitle.recentcitations 第一作者 Yoon, Y 标题 Salivary gland organoid culture maintains distinct glandular properties of murine and human major salivary glands. 文献引用 Nature Communications; 13(1) pg3291 PubMed Id 35672412 第一作者 Ryu, T Y 标题 Human gut-microbiome-derived propionate coordinates proteasomal degradation via HECTD2 upregulation to target EHMT2 in colorectal cancer. 文献引用 The ISME Journal; 16(5) pg1205-1221 PubMed Id 34972816 第一作者 Buchanan, K L 标题 The preference for sugar over sweetener depends on a gut sensor cell. 文献引用 Nature Neuroscience; 25(2) pg191-200 PubMed Id 35027761 product.subtitle.productreviews 现有评论 Perfect for organoid culture My lung organoids grow well consistently even after passaging it couple of times and there were no contamination issues. 来自: Eun Joo | 日期: 2020/7/8 × Perfect for organoid culture My lung organoids grow well consistently even after passaging it couple of times and there were no contamination issues. 来自: Eun Joo | 日期: 2020/7/8 Close Good for organoid This is good for my primary lung organoid culture. 来自: Jun | 日期: 2020/7/21 × Good for organoid This is good for my primary lung organoid culture. 来自: Jun | 日期: 2020/7/21 Close High quality and good price This product worked well for my project. The price is reasonable and lower than most of vendors. 来自: Jin | 日期: 2020/8/26 × High quality and good price This product worked well for my project. The price is reasonable and lower than most of vendors. 来自: Jin | 日期: 2020/8/26 Close Excellent qualiity We have been using recombinant human R-spondin-1 for over 6 years and have been absolutely satisfied with the quality, purity, and performance! 来自: Candace | 日期: 2021/8/3 × Excellent qualiity We have been using recombinant human R-spondin-1 for over 6 years and have been absolutely satisfied with the quality, purity, and performance! 来自: Candace | 日期: 2021/8/3 Close
