Animal-Free Recombinant Human SCF 1 评论Submit a Review 产品详情 产品编号: AF-300-07 产品描述: SCF is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on murine cells, while murine and rat SCF are fully active on human cells. The human SCF gene encodes for a 273 amino acid transmembrane protein, which contains a 25 amino acid N-terminal signal sequence, a 189 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 36 amino acid cytoplasmic domain. The secreted soluble form of SCF is generated by proteolytic processing of the membrane anchored precursor. Recombinant Human SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Stem Cell Factor, c-Kit Ligand, Mast Cell Growth Factor (MGF), Steel Factor AA Sequence: MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. Calculated Molecular Weight: 18.4 kDa Accession Number: P21583 Gene ID: 4254 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Human, Monkey, Mouse, Rabbit References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 细胞培养 免疫系统 干细胞&分化 product.subtitle.recentcitations 第一作者 King, A J 标题 Reactivation of a developmentally silenced embryonic globin gene 文献引用 Nature Communications; 12(1) pg4439 PubMed Id 34290235 第一作者 Giuli, M V 标题 Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response 文献引用 Oncogenesis; 9(10) pg93 PubMed Id 33071287 第一作者 Thomé, C H 标题 NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia 文献引用 Scientific Reports; 10(1) pg10315 PubMed Id 32587277 product.subtitle.productreviews 现有评论 For differentiation macrophage progenitors. I have been using this human SCF for differentiating macrophage progenitors. It worked perfectly, and I definitely recommend. 来自: Yongjin | 日期: 2020/8/26 × For differentiation macrophage progenitors. I have been using this human SCF for differentiating macrophage progenitors. It worked perfectly, and I definitely recommend. 来自: Yongjin | 日期: 2020/8/26 Close