Recombinant Human sTRAIL Receptor-2 0 评论Submit a Review 产品详情 产品编号： 310-19 产品描述： TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins, and contain a cytoplasmic "death domain," which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane-anchored or soluble TRAIL/Apo2L. The DR4 and DR5 receptors are both produced as type I transmembrane proteins, which contain an extracellular domain, a transmembrane domain, and a cytoplasmic domain. The recombinant soluble forms of DR4 and DR5 consist of the TNFR-homologous, cysteine-rich portion of their respective extracellular domains. Recombinant Human soluble TRAIL Receptor-2/DR5 is a 14.9 kDa protein (133 amino acid residues) consisting of the TNFR-homologous, cysteine-rich portion of the extracellular domain. Source: E.coli Synonyms: soluble TRAIL Receptor-2, DR5, TNFRSF10B, KILER, TRICK2A, TRICKB AA Sequence: MESALITQQD LAPQQRVAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KES Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit apoptosis induced by Human sTRAIL/Apo2L in LN-18 cells (human glioblastoma cells). Calculated Molecular Weight: 14.9 kDa Accession Number: O14763 Gene ID: 8795 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 癌症 免疫系统 受体 TNF超家族 product.subtitle.recentcitations 第一作者 Lee, J 标题 Functional consequences of complementarity-determining region deactivation in a multifunctional anti-nucleic acid antibody. 文献引用 The Journal of Biological Chemistry; 288(50) pg35877-85 PubMed Id 24155236 第一作者 Reis, C R 标题 Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors. 文献引用 Molecular & cellular proteomics : MCP; 10(1) pgM110.002808 PubMed Id 20852190
