Recombinant Human TGF-β2 (HEK293 derived) 0 评论Submit a Review 产品详情 产品编号: 100-35B 产品描述: The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2-dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immunosurveillance of tumor development. Recombinant Human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond. Source: HEK293 cells Synonyms: Transforming Growth Factor-β2, Glioblastoma-derived T cell suppressor factor, BSC-1, Cetermin, Polyergin AA Sequence (monomer): ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The ED50 was found to be ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg. Calculated Molecular Weight: 25 kDa Accession Number: P61812 Gene ID: 7042 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 250μg is the largest vial size for this product. Larger sizes supplied as multiple 250μg vials. crossreactivity: Human, Human + Virus, Mouse, Mouse + Rat, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 细胞凋亡 骨/骨骼系统/软骨 癌症 细胞培养 免疫系统 炎症 神经生物学 干细胞&分化 TGF-β超家族 创伤修复 过敏 product.subtitle.recentcitations 第一作者 Cook, J R 标题 LRRC8A is dispensable for a variety of microglial functions and response to acute stroke. 文献引用 Glia; 70(6) pg1068-1083 PubMed Id 35150591 第一作者 Lecce, L 标题 Histone deacetylase 9 promotes endothelial-mesenchymal transition and an unfavorable atherosclerotic plaque phenotype. 文献引用 The Journal of Clinical Investigation; 131(15) PubMed Id 34338228 第一作者 Srivastava, S P 标题 Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy 文献引用 Nature Communications; 12(1) pg2368 PubMed Id 33888696