Recombinant Murine IFN-γ

产品详情

产品编号： 315-05

产品描述：

IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes, as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting, cells and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ is species-specific and is biologically active only in human and primate cells. Recombinant Murine IFN-γ is a 15.6 kDa protein containing 134 amino acid residues.

Source: E.coli

Synonyms: Immune Interferon, type II interferon, T cell interferon, MAF

AA Sequence: MHGTVIESLE SLNNYFNSSG IDVEEKSLFL DIWRNWQKDG DMKILQSQII SFYLRLFEVL KDNQAISNNI SVIESHLITT FFSNSKAKKD AFMSIAKFEV NNPQVQRQAF NELIRVVHQL LPESSLRKRK RSRC

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit the proliferation of murine WEHI-279 cells. The expected ED₅₀ is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10⁶ units/mg.

Calculated Molecular Weight: 15.6 kDa

Accession Number: P01580

Gene ID: 15978

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:

Cow, Human, Human + Mouse, Mouse, Mouse + Chicken, Mouse + Parasite, Rabbit, Rat, Vole

Country Of Origin: USA

Not for human use.

Research Interest

癌症

免疫系统

过敏

product.subtitle.recentcitations

第一作者

Kieckhöfer, E

标题

Primary cilia suppress Ripk3-mediated necroptosis.

文献引用

Cell Death Discovery; 8(1) pg477

PubMed Id

36460631

第一作者

Kang, T G

标题

Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx.

文献引用

Nature Communications; 13(1) pg3155

PubMed Id

35672321

第一作者

Greene, C J

标题

Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes.

文献引用

Nature Communications; 13(1) pg3072

PubMed Id

35654768

product.subtitle.productreviews

现有评论

Recombinant Murine IFN-γ

This product Recombinant Murine IFN-γ was used successfully for our signaling in vitro experiments for the use of CD4, CD8, macrophages as well as the expression of INF-γ. Cells used were mouse lymphocytes isolated from the mouse spleen.

来自: Linda | 日期: 2020/7/8

Recombinant Murine IFN-γ

Works well for priming our bone-marrow derived macrophages

来自: MCBL | 日期: 2020/8/7

Best cytokine of its kind

Have been using it for a long time for our in-vivo pump experiments and it has been a breeze working with this product. It never fails to perform.

来自: Vineet | 日期: 2020/8/10

Great consistent cytokine for differentiation of Th1 cells and M1 macrophages

We routinely use this cytokine to generate mouse CD4 Th1 cells and M1 polarized macrophages. The pricing and consistency of this cytokine can't be beat, and we have been using it for almost 20 years. All of our cytokines used in our lab are from peprotech.

来自: Chirag | 日期: 2020/8/31

生长因子和细胞因子