Recombinant Murine IGF-I 0 评论Submit a Review 产品详情 产品编号: 250-19 产品描述: The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant Murine IGF-I is a 7.6 kDa globular protein containing amino acids including 3 intra-molecular disulfide bonds. Source: E.coli Synonyms: Insulin-like Growth Factor-I, Somatamedin C, IGF-IA AA Sequence: GPETLCGAEL VDALQFVCGP RGFYFNKPTG YGSSIRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPTKAA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. Calculated Molecular Weight: 7.6 kDa Accession Number: P05017 Gene ID: 16000 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Pig, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 骨/骨骼系统/软骨 糖尿病/体重调节 免疫系统 炎症 神经生物学 干细胞&分化 创伤修复 product.subtitle.recentcitations 第一作者 Dowery, R 标题 Peripheral B cells repress B-cell regeneration in aging through a TNF-α/IGFBP-1/IGF-1 immune-endocrine axis. 文献引用 Blood; 138(19) pg1817-1829 PubMed Id 34297797 第一作者 Dignum, T 标题 Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo. 文献引用 Cell Reports; 36(11) pg109675 PubMed Id 34525376 第一作者 Rore, H 标题 Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells 文献引用 Communications Biology; 4(1) pg802 PubMed Id 34183774