Recombinant Murine IL-11 0 评论Submit a Review 产品详情 产品编号： 220-11 产品描述： IL-11 is a multifunctional cytokine produced by stromal cells, such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues, including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines, and protects against gastromucosal injury. Recombinant Murine IL-11 is a 19.1 kDa protein consisting of 179 amino acid residues. Source: E.coli Synonyms: AGIF (Adipogenesis inhibitory factor) AA Sequence: MPGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. Calculated Molecular Weight: 19.1 kDa Accession Number: P47873 Gene ID: 16156 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Mouse References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 细胞凋亡 癌症 免疫系统 炎症 神经生物学 干细胞&分化 product.subtitle.recentcitations 第一作者 Cova, G 标题 Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells. 文献引用 The Journal of Experimental Medicine; 218(10) PubMed Id 34459852 第一作者 Ho, T T 标题 Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions. 文献引用 The Journal of Experimental Medicine; 218(7) PubMed Id 34032859 第一作者 Numata, A 标题 Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance. 文献引用 Blood; 136(15) pg1735-1747 PubMed Id 32542325
