Animal-Free Recombinant Murine TPO 0 评论Submit a Review 产品详情 产品编号： AF-315-14 产品描述： TPO is a lineage-specific growth factor produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor, and acts as an important regulator of circulating platelets. Human and murine TPO exhibit cross-species reactivity. Recombinant Murine TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF AA Sequence: SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. Calculated Molecular Weight: 18.7 kDa Accession Number: P40226 Gene ID: 21832 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 细胞培养 免疫系统 干细胞&分化 创伤修复 product.subtitle.recentcitations 第一作者 Ambrosi, T H 标题 Aged skeletal stem cells generate an inflammatory degenerative niche 文献引用 Nature; 597(7875) pg256-262 PubMed Id 34381212 第一作者 Ochi, K 标题 Non-conditioned bone marrow chimeric mouse generation using culture-based enrichment of hematopoietic stem and progenitor cells 文献引用 Nature Communications; 12(1) pg3568 PubMed Id 34117255 第一作者 Wilkinson, A C 标题 Long-term ex vivo expansion of mouse hematopoietic stem cells. 文献引用 Nature Protocols; 15(2) pg628-648 PubMed Id 31915389
