Recombinant Rat IL-10 0 评论Submit a Review 产品详情 产品编号: 400-19 产品描述: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-α. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 is active on murine cells, but murine IL-10 is inactive on human cells. Recombinant Rat IL-10 is an 18.7 kDa protein of 160 amino acid residues. Source: E.coli Synonyms: B-TCGF, CSIF, TGIF AA Sequence: SKGHSIKGDN NCTHFPVSQT HMLRELRAAF SQVKTFFQKK DQLDNIVLTD SLLQDFKGYL GCQALSEMIK FYLVEVMPQA ENHGPEIKEH LNSLGEKLKT LWIQLRRCHR FLPCENKSKA VEQVKNDFNK LQDKGVYKAM NEFDIFINCI EAYVTLKMKN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent inhibition of antigen-specific T cell proliferation is ≤10ng/ml. Calculated Molecular Weight: 18.7 kDa Accession Number: P29456 Gene ID: 25325 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 艾滋病/HIV 癌症 免疫系统 炎症 神经生物学 干细胞&分化 过敏 移植 product.subtitle.recentcitations 第一作者 Schneider, D J 标题 Mechanisms and modulation of microvesicle uptake in a model of alveolar cell communication. 文献引用 The Journal of Biological Chemistry; 292(51) pg20897-20910 PubMed Id 29101235 第一作者 Chen, H 标题 IL-10 Promotes Neurite Outgrowth and Synapse Formation in Cultured Cortical Neurons after the Oxygen-Glucose Deprivation via JAK1/STAT3 Pathway. 文献引用 Scientific Reports; 6 pg30459 PubMed Id 27456198 第一作者 Duhamel, M 标题 Molecular Consequences of Proprotein Convertase 1/3 (PC1/3) Inhibition in Macrophages for Application to Cancer Immunotherapy: A Proteomic Study. 文献引用 Molecular & cellular proteomics : MCP; 14(11) pg2857-77 PubMed Id 26330543