Recombinant Human EPO 0 ComentariosSubmit a Review Detalles del Producto Nùmero de Catalogo 100-64 Descripcion Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EPO in adult mammals are maintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by the liver. EPO also can exert various non-hematopoietic activities, including vascularization and proliferation of smooth muscle, neural protection during hypoxia, and stimulation of certain B cells. PeproTech’s Human EPO contains 166 amino acid residues and has a calculated molecular weight of approximately 18.4 kDa. As a result of glycosylation, Recombinant Human EPO migrates with an apparent molecular mass of 37.0 kDa by SDS-PAGE gel, under reducing and non-reducing conditions. Source: CHO cells Synonyms: Erythropoietin, Epoetin AA Sequence: APPRLICDSR VLERYLLEAK EAENITTGCA EHCSLNENIT VPDTKVNFYA WKRMEVGQQA VEVWQGLALL SEAVLRGQAL LVNSSQPWEP LQLHVDKAVS GLRSLTTLLR ALGAQKEAIS PPDAASAAPL RTITADTFRK LFRVYSNFLR GKLKLYTGEA CRTGDR Purity: ≥ 90% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by a cell proliferation assay using TF-1 cells. The expected ED50 for this effect is 0.8-1.0 ng/ml. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 18.4 kDa Accession Number: P01588 Gene ID: 2056 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Human + Virus, Mouse References PubMed SDS Búsqueda del CoA Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Immune System Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations Primer autor Chen, W Titulo Reprogramming of human peripheral blood mononuclear cells into induced mesenchymal stromal cells using non-integrating vectors. Citar Communications Biology; 6(1) pg393 PudMed id 37041280 Primer autor Atkins, M H Titulo Modeling human yolk sac hematopoiesis with pluripotent stem cells. Citar The Journal of Experimental Medicine; 219(3) PudMed id 34928315 Primer autor Ito, K Titulo Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics. Citar Communications Biology; 5(1) pg56 PudMed id 35031676