Recombinant Human IL-31 0 ComentariosSubmit a Review Detalles del Producto Nùmero de Catalogo 200-31 Descripcion Human IL-31 is a T cell-derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (also known as gp130-like receptor or IL-31RA) and Oncostatin-M receptor (OSMR). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, JAK1, and JAK2 signaling pathways. IL-31-regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant Human IL-31 is a 15.8 kDa protein containing 141 amino acid residues. Source: E.coli Synonyms: Interleukin-31 AA Sequence: SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to induce STAT3 activation in human U87 cells. Calculated Molecular Weight: 15.8 kDa Accession Number: Q6EBC2 Gene ID: 386653 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, References PubMed SDS Búsqueda del CoA Product Line Country Of Origin: USA Not for human use. Research Interest Immune System Inflammation Stem Cells & Differentiation product.subtitle.recentcitations Primer autor Braz, J M Titulo Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness. Citar Proceedings of the National Academy of Sciences of the United States of America; 118(8) PudMed id 33602818 Primer autor Umehara, Y Titulo Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells. Citar Scientific Reports; 10(1) pg4360 PudMed id 32152328 Primer autor Raap, U Titulo Human basophils are a source of - and are differentially activated by - IL-31. Citar Clinical And Experimental Allergy : Journal Of The British Society For Allergy And Clinical Immunology; 47(4) pg499-508 PudMed id 28000952
