Animal-Free Recombinant Human NT-3

Detalles del Producto

Nùmero de Catalogo AF-450-03

Descripcion

NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous system, and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues).

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Neurotrophin-3, Neurotrophic factor, Nerve growth factor-2, NGF-2, HGNF

AA Sequence (monomer): MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.

Calculated Molecular Weight: 27.2 kDa

Accession Number: P20783

Gene ID: 4908

Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)

crossreactivity:

Human, Mouse, Rat