Recombinant Human PDGF-AA 0 ComentariosSubmit a Review Detalles del Producto Nùmero de Catalogo 100-13A Descripcion PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids). Source: E.coli Synonyms: Platelet-Derived Growth Factor-AA, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF) AA Sequence (monomer): SIEEAVPAV CKTRTVIYEI PRSQVDPTSA NFLIWPPCVE VKRCTGCCNT SSVKCQPSRV HHRSVKVAKV EYVRKKPKLK EVQVRLEEHL ECACATTSLN PDYREEDTGR PRESGKKRKR KRLKPT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 1.0-3.0 ng/ml. Calculated Molecular Weight: 28.5 kDa Accession Number: P04085 Gene ID: 5154 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Alpaca, Dog, Human, Lizard, Monkey, Mouse, Rat, Salamander, Zebra Fish References PubMed SDS Búsqueda del CoA Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Cancer Immune System Neurobiology Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations Primer autor Yun, W Titulo OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease. Citar NPJ Regenerative Medicine; 7(1) pg4 PudMed id 35027563 Primer autor Luo, Y Titulo Platelet-Derived Growth Factor-Functionalized Scaffolds for the Recruitment of Synovial Mesenchymal Stem Cells for Osteochondral Repair. Citar Stem Cells International; 2022 pg2190447 PudMed id 35126525 Primer autor Guttenplan, K A Titulo Neurotoxic reactive astrocytes induce cell death via saturated lipids Citar Nature; 599(7883) pg102-107 PudMed id 34616039