Recombinant Human Pleiotrophin 0 ComentariosSubmit a Review Detalles del Producto Nùmero de Catalogo 450-15 Descripcion Pleiotrophin and Midkine are structurally related heparin-binding neurotrophic factors, whose expression is developmentally regulated. The expression pattern of these neurotrophic factors suggests function in neurogenesis, cell migration, secondary organogenetic induction, and mesoderm epithelial interaction. The expression of PTN increases during the process of brain embryogenesis, and reaches maximum levels at time of birth. The physiological roles of PTN and Midkine are largely unknown, but these neurotrophins have been implicated in the pathogenesis of neuroblastomas. Recombinant Human Pleiotrophin is a 15.4 kDa protein containing 136 amino acid residues and five intra-molecular disulfide bonds. Source: E.coli Synonyms: PTN, Heparin Affin Regulatory Protein (HARP), Heparin-binding growth factor-8(HBGF-8), Osteoblast-Specific Factor-1 (OSF-1) AA Sequence: GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Not available. Calculated Molecular Weight: 15.4 kDa Accession Number: P21246 Gene ID: 5764 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Chicken, Hamster, Human, Mouse, Rat References PubMed SDS Búsqueda del CoA Product Line Country Of Origin: USA Not for human use. Research Interest Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations Primer autor Notaras, M Titulo Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids. Citar Molecular Psychiatry; 27(3) pg1416-1434 PudMed id 34789849 Primer autor Arnold, N Titulo A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension. Citar Nature Communications; 10(1) pg5183 PudMed id 31729368 Primer autor Lampropoulou, E Titulo Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration. Citar Scientific Reports; 8(1) pg5893 PudMed id 29651006
