Recombinant Human TGF-β2 (HEK293 derived) 0 ComentariosSubmit a Review Detalles del Producto Nùmero de Catalogo 100-35B Descripcion The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2-dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immunosurveillance of tumor development. Recombinant Human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond. Source: HEK293 cells Synonyms: Transforming Growth Factor-β2, Glioblastoma-derived T cell suppressor factor, BSC-1, Cetermin, Polyergin AA Sequence (monomer): ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The ED50 was found to be ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg. Calculated Molecular Weight: 25 kDa Accession Number: P61812 Gene ID: 7042 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 250μg is the largest vial size for this product. Larger sizes supplied as multiple 250μg vials. crossreactivity: Human, Human + Virus, Mouse, Mouse + Rat, Rat References PubMed SDS Búsqueda del CoA Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Bone, Skeletal, Cartilage Cancer Cell Culture Immune System Inflammation Neurobiology Stem Cells & Differentiation TGF-β Superfamily Wound Healing Allergy product.subtitle.recentcitations Primer autor Cook, J R Titulo LRRC8A is dispensable for a variety of microglial functions and response to acute stroke. Citar Glia; 70(6) pg1068-1083 PudMed id 35150591 Primer autor Lecce, L Titulo Histone deacetylase 9 promotes endothelial-mesenchymal transition and an unfavorable atherosclerotic plaque phenotype. Citar The Journal of Clinical Investigation; 131(15) PudMed id 34338228 Primer autor Srivastava, S P Titulo Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy Citar Nature Communications; 12(1) pg2368 PudMed id 33888696